Registration Dossier
Registration Dossier
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EC number: 230-601-5 | CAS number: 7214-18-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Ames test: Negative (OECD TG 471, GLP)
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Ames test: The substance is tested in the Ames test according to OECD TG 471 and following GLP to investigate its potential to induce gene mutations according to the plate incorporation test (experiment I) and the pre-incubation test (experiment II) using Salmonella typhimurium strains TA98, TA100, TA1535, TA1537 and tester strain E. coli WP2 uvrA (pKM101). Based on a pre-experiment, concentrations of up to 2500 μg/plate were selected for the main experiments. The dose range was 3.16 to 2500 μg/plate in experiment I and 1.00 to 1000 μg/plate in experiment II. The concentrations were tested in triplicate both with and without metabolic activation. No precipitation of the test item was observed in any tester strain used in experiment I and II (with and without metabolic activation). Cytotoxicity was observed in both the experiments with and without metabolic activation. However, no biologically relevant increases in revertant colony numbers of any of the five tester strains were observed following treatment with the test substance at any concentration level, neither in the presence nor absence of metabolic activation in experiment I and II. The test substance was considered to be non-mutagenic under the conditions of this test.
Justification for classification or non-classification
Based on the results of the Ames test, the substance does not need to be classified for genotoxicity according to EU CLP (EC 1272/2008 and its amendments).
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