Registration Dossier
Registration Dossier
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EC number: 230-601-5 | CAS number: 7214-18-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
For the substance an EC50 of 2.08 mg/L for Daphnia is derived, based on ECOSAR prediction using the measured log Kow of 3.8.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 2.08 mg/L
Additional information
The acute Daphnia EC50 for the neutral organic Verdol is predicted to be 2.08 mg/L based on the ECOSAR SAR for neutral organics using a measured log Kow of 3.8, molecular weight of 156.27 and the equation: Log 48h-LC50 (mmol/L) = -0.858 Log Kow + 1.3848. When using the estimated log Kow value of 3.42, the 48h EC 50 is 4.43 mg/l. The LC50 in ECOSAR is considered equivalent to the EC50 as defined in OECD TG 202.
Verdol is in the applicability domain of the ECOSAR prediction because: a) the substance is a Neutral Organic presenting the toxicity solely by its bioavailability (i.e. without fragments that activate this Neutral Organic); b) its log Kow is 3.8 (=< 5); c) its MW is 152.27 (< 1000); and; d) the toxicity predicted is below its water solubility of 613 mg/L.
The measured and predicted log Kow values of the substance are 3.8 and 3.41, respectively and therefore present limited uncertainty as the log Kow difference is < 0.5. Also, the measured log Kow of 3.8 is used presenting a conservative value (a lower EC50).
This shows that the prediction is reliable and a Klimisch 2 can be assigned. In accordance with REACH Annex XI, the validity of the (Q)SAR is documented in a QMR for acute Daphnia toxicity on neutral organics (see attached report in study record). The adequate and reliable documentation presented further supports this prediction.
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