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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
relative density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
05 Oct 2020 to 04 Dec 2020
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2021
Report date:
2021

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.3 (Relative Density)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7300 (Density / Relative Density / Bulk Density)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
pycnometer method

Test material

Constituent 1
Chemical structure
Reference substance name:
N-{5-[(4-{4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl}pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl}prop-2-enamide
EC Number:
841-500-6
Cas Number:
1903008-80-9
Molecular formula:
C30H34N8O3
IUPAC Name:
N-{5-[(4-{4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl}pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl}prop-2-enamide
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- lot/batch number of test material: M20BD0542
- Expiry date: 19 February 2022 (retest date)
- Physical Description: Slightly greenish yellow powder
- Purity: 99.8%
- Purity correction factor: 1.00

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Final preparation of a solid: prior to use in the study, the test material was dried in a desiccator under vacuum using silicagel as the drying agent at 20.2 ± 1.0°C in dark for 73.7 hours.

Results and discussion

Densityopen allclose all
Type:
density
Density:
1.29 g/cm³
Temp.:
20 °C
Remarks on result:
other: The individual measurements were obtained with an accuracy of < 0.02 g/cm3 . According to the guideline, the density of the test item is given as the mean value.
Key result
Type:
relative density
Density:
1.29
Temp.:
20 °C
Remarks on result:
other: The individual measurements were obtained with an accuracy of < 0.02 g/cm3. According to the guideline, the density of the test item is given as the mean value.

Any other information on results incl. tables

The results of the tests on the determination of the density of the test item are given in the table below



















































 



Test 1



Test 2



Sample mass (g)



4.5006



4.6984



Sample volume (cm3)



3.4901



3.6246



3.4881



3.6236



3.4890



3.6334



3.4884



3.6295



3.4904



3.6350



Average volume (cm3)



3.4892±0.0009



3.6292±0.0045



Density (g/cm3)



1.290



1.295



Mean density (g/cm3)



1.29



The individual measurements were obtained with an accuracy of < 0.02 g/cm3. According to the guideline, the density of the test item is given as the mean value.

Applicant's summary and conclusion

Conclusions:
A gas comparison stereopycnometer was used for the determination of the density and relative density of JNJ-73841937-AAA (T003925).
The density of the test item at 20ºC was 1.29 g/cm³ (1.29 x 10³ kg/m³).
The relative density was 1.29.