Registration Dossier
Registration Dossier
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EC number: 841-500-6 | CAS number: 1903008-80-9
Flammability
Administrative data
- Endpoint:
- flammable solids
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05 Oct 2020 to 04 Dec 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.10 (Flammability (Solids))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- N-{5-[(4-{4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl}pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl}prop-2-enamide
- EC Number:
- 841-500-6
- Cas Number:
- 1903008-80-9
- Molecular formula:
- C30H34N8O3
- IUPAC Name:
- N-{5-[(4-{4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl}pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl}prop-2-enamide
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- lot/batch number of test material: M20BD0542
- Expiry date: 19 February 2022 (retest date)
- Physical Description: Slightly greenish yellow powder
- Purity: 99.8%
- Purity correction factor: 1.00
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
Results and discussion
Flammable solids
- Key result
- Test procedure:
- burning rate test: preliminary screening test
- Burning time:
- 1 s
Any other information on results incl. tables
The flame of the gas burner did ignite the test item pile. The test item melted, burned with a yellow flame and turned into a red/black residue. White smoke was observed. After removal of the ignition source, the flame extinguished after 1 second and no propagation of combustion was observed.
Applicant's summary and conclusion
- Conclusions:
- The preliminary screening test was performed for the determination of the flammability of JNJ-73841937-AAA (T003925).
No propagation of combustion of the test item along 200 mm length of the pile within 2 minutes
was observed. According to the guidelines, performance of the burning rate test is not required.
Based on the results obtained, the test item should be considered ‘not flammable’ according to the classification criteria under Regulation (EC) No 1272/2008 for flammable solids.
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