Registration Dossier
Registration Dossier
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EC number: 841-500-6 | CAS number: 1903008-80-9
Auto flammability
Administrative data
- Endpoint:
- relative self-ignition temperature (solids)
- Remarks:
- powder
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05 Oct 2020 to 04 Dec 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.16 (Relative Self-Ignition Temperature for Solids)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- N-{5-[(4-{4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl}pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl}prop-2-enamide
- EC Number:
- 841-500-6
- Cas Number:
- 1903008-80-9
- Molecular formula:
- C30H34N8O3
- IUPAC Name:
- N-{5-[(4-{4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl}pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl}prop-2-enamide
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- lot/batch number of test material: M20BD0542
- Expiry date: 19 February 2022 (retest date)
- Physical Description: Slightly greenish yellow powder
- Purity: 99.8%
- Purity correction factor: 1.00
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
Results and discussion
Relative self-ignition temperature (solids)
- Key result
- Remarks on result:
- no self-ignition observed up to the melting point
Any other information on results incl. tables
No significant endothermic or exothermic effect of the test item was observed between 20°C and 221.2°C (i.e. the melting temperature of the test item; see Chapter 7). It demonstrated that the test item is not self-ignitable.
After the experiment, the test item had turned into a black charred expanded residue and was collected in a container that was placed below the cube. It indicated that the test item had been molten, decomposed and/or reacted during the experiment.
Applicant's summary and conclusion
- Conclusions:
- The self-ignition temperature of JNJ-73841937-AAA (T003925) was determined using a temperature programmed laboratory oven, a stainless steel wire mesh cube, NiCr/NiAl thermocouples and a temperature recording device.
Based on the results obtained the test item is considered ‘not self-ignitable’.
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