Registration Dossier
Registration Dossier
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EC number: 266-257-8 | CAS number: 66215-27-8
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991/10/09 to 1992/05/05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- This experimental study report is reliable as it has been conducted by a trusted laboratory, under GLP and following OECD Guidelines.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Remarks:
- flask-shaking method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- Pow
- Partition coefficient:
- 0.913
- Temp.:
- 25 °C
- pH:
- 9
- Key result
- Type:
- Pow
- Partition coefficient:
- 0.869
- Temp.:
- 25 °C
- pH:
- 7
- Key result
- Type:
- Pow
- Partition coefficient:
- 0.709
- Temp.:
- 25 °C
- pH:
- 5
- Conclusions:
- The octanol/water partition coefficient of the test substance was found to be 0.7088 ± 0.0185 (log Pow = -0.1506 ± 0.0097) in pH 5 buffer solution, 0.8686 ± 0.0183 (log Pow = -0.0613 ± 0.0091) in pH 7 buffer solution, and 0.9135 ± 0.0182 (log Pow= -0.0394 ± 0.0087) in pH 9 buffer solution at 25°C.
- Executive summary:
The partition coefficient of the test substance has been determined using flask-shaking method. The study was perfomed in accordance with the OECD Guideline 107. The octanol/water partition coefficient of the test substance was found to be 0.7088 ± 0.0185 (log Pow = -0.1506 ± 0.0097) in pH 5 buffer solution, 0.8686 ± 0.0183 (log Pow = -0.0613 ± 0.0091) in pH 7 buffer solution, and 0.9135 ± 0.0182 (log Pow= -0.0394 ± 0.0087) in pH 9 buffer solution at 25°C.
Reference
Description of key information
The octanol/water partition coefficient of the test substance was found to be 0.7088 ± 0.0185 (log Pow = -0.1506 ± 0.0097) in pH 5 buffer solution; 0.8686 ± 0.0183 (log Pow = -0.0613 ± 0.0091) in pH 7 buffer solution; 0.9135 ± 0.0182 (log Pow= -0.0394 ± 0.0087) in pH 9 buffer solution at 25°C, OECD Guideline 107, Rodler 1992.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.061
- at the temperature of:
- 25 °C
Additional information
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