Diethyl sebacate

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

GLP compliance:

not specified

Remarks:

not specified in the report

Analytical monitoring:

yes

Vehicle:

no

Test organisms (species):

Daphnia magna

Details on test organisms:

Daphnia magna Straus (Cladocera, Crustacea) obtained by acyclic parthenogenesis under the rearing conditions defined by the laboratory and less than 24 hours old.

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Test temperature:

20°C

pH:

7.7

Dissolved oxygen:

8.7 mg/L

Reference substance (positive control):

yes

Remarks:

Potassium dichromate

Key result

Duration:

48 h

Dose descriptor:

EL50

Effect conc.:

>= 10 - <= 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat. (dissolved fraction)

Remarks:

WAF

Basis for effect:

mobility

Details on results:

Please, see the attached study report

Validity criteria fulfilled:

yes

Conclusions:

Under the experimental conditions, the registered substance exhibits an EL50 between 10 and 100 mg/L (loading rate).

Executive summary:

For that endpoint, one reliable study to assess the acute toxicity on the registered substance on aquatic invertebrates (Daphnia magna) was available. The study was performed according to the OECD 202 guideline.

Since the registered substance is insoluble in water, Water Accommodated Fractions (WAFs) were prepared at each concentration tested. WAFs were prepared at concentrations of 1, 10, and 100 mg/L as loading rates. The suspensions were weighed and transferred to a volume of mineral medium and then extracted by orbital agitation for 24 hours followed by filtration at 0.45 μm.

Under the experimental conditions, the registered substance exhibits an EL50 between 10 and 100 mg/L (loading rate).

The validity criteria were successful and the study was therefore regarded as acceptable for that endpoint.

Description of key information

For that endpoint, one reliable study to assess the acute toxicity on the registered substance on aquatic invertebrates (Daphnia magna) was available. The study was performed according to the OECD 202 guideline.

Since the registered substance is insoluble in water, Water Accommodated Fractions (WAFs) were prepared at each concentration tested. WAFs were prepared at concentrations of 1, 10, and 100 mg/L as loading rates. The suspensions were weighed and transferred to a volume of mineral medium and then extracted by orbital agitation for 24 hours followed by filtration at 0.45 μm.

Under the experimental conditions, the registered substance exhibits an EL50 between 10 and 100 mg/L (loading rate).

The validity criteria were successful and the study was therefore regarded as acceptable for that endpoint.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

10 mg/L