Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-836-1 | CAS number: 25321-14-6
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliabiliy as cited in OECD SIDS Dinitrotoluene (isomers mixture) CAS No.: 25321-14-6, 2004. limited documentation
Data source
Reference
- Title:
- Lack of an Indication of Mutagenic Effects of Dinitrotoluenes and Diaminotoluenes in Mice
- Author:
- Soares, E.R. and Lock, L.F.
- Year:
- 1 980
- Bibliographic source:
- Environmental Mutagenesis 2: 111-124
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Dinitrotoluene
- EC Number:
- 246-836-1
- EC Name:
- Dinitrotoluene
- Cas Number:
- 25321-14-6
- Molecular formula:
- C7H6N2O4
- IUPAC Name:
- 1-methyl-2,4-dinitrobenzene; 2-methyl-1,3-dinitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 2,4-DNT (technical grade)
- Composition of test material, percentage of components: 2,3-DNT (1.5%), 2,4-DNT (75.8%), 2,5-DNT (0.7%), 2,6-DNT (19.5%), 3,4-DNT (2.5 %), 3,5-DNT (o.04%)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: DBA/2J
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Doses:
- 500 mg 2,4-DNT/kg bw
- No. of animals per sex per dose:
- not stated
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 500 mg/kg bw
- Remarks on result:
- other: LD50(24h); no deaths
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
