Dipotassium titanium oxide dioxalate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2019

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Dipotassium titanium oxide dioxalate

EC Number:

238-475-3

EC Name:

Dipotassium titanium oxide dioxalate

Cas Number:

14481-26-6

Molecular formula:

C4K2O9Ti

IUPAC Name:

dipotassium oxotitaniumbis(ylium) dioxalate

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

DMSO

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

6 female rats were administered the dose 2000 mg/kg bw.

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

One mortality was noted in animals treated at the dose of 2000 mg/kg bw at 24 hours post-dose. The mortality was preceded by a decrease in spontaneous activity, 30 minutes and 1 hour post dose.
The macroscopic examination of the animal revealed brown liquid in the stomach, thinning of the fundus, white and purple coloration of the corpus and red liquid in intestines.

Clinical signs:

In the surviving animals (5/6), no clinical signs related to the administration of the test item were observed during the study.

Body weight:

The body weight evolution of the animal remained normal throughout the study.

Gross pathology:

The macroscopic examination of the animals at the end of the study did not reveal treatment related changes.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

In conclusion, the LD50 of the test item Oxalate de Titanyl Potassium is higher than 2000 mg/kg bw. In accordance with the OECD 423, the LD50 cut-off of the test item may be considered as 2500 mg/kg bw by oral route in the rat.