Registration Dossier
Registration Dossier
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EC number: 231-326-3 | CAS number: 7492-70-8
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 Apr 2018 to 04 Jun 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 27 July 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 04 March 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- March 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- Appearance: Colourless liquid
Test item storage: At room temperature - Key result
- Water solubility:
- 0.28 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- >= 6.4 - <= 6.8
- Conclusions:
- The water solubility of the test substance was found to be 0.280 g/l at 20 °C, under the conditions of the test.
- Executive summary:
In this guideline (OECD 105) study, conducted with GLP certification, the water solubility of the test substance was found to be 0.280 g/l at 20 °C.
Reference
Preliminary Test
The content of test item dissolved in the water sample was 0.235 g/L.
Main Study
The results for the samples taken at 24, 48 and 72 hours are given in Table 6 (attached below). The 24-hour measurement was significantly lower than the 48- and 72- hour measurements (maximum difference > 15%). Based on this, the water solubility of the test item was given as the mean value of the 48- and 72-hour measurements.
A small response at the retention time of the test item was observed in the chromatogram of the pretreated sample from the blank water mixture. It was not considered to derive from the water sample since a similar response was obtained in the analytical blanks.
In order to investigate whether the test item dissolves more with prolonged stirring time (slightly trend in the concentration increase is seen), samples were measured once more afteradditional stirring time. Since no increase in the concentration was seen results of the originalstirring time are reported as water solubility (prolonged stirring time results are archived in raw data).
Description of key information
Study conducted to recognised testing guidelines with GLP certification.
Key value for chemical safety assessment
- Water solubility:
- 0.28 g/L
- at the temperature of:
- 20 °C
Additional information
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