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EC number: 288-752-8 | CAS number: 85895-78-9
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2020-05-25 to 2020-05-27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- no
- GLP compliance:
- no
- Specific details on test material used for the study:
- - Test item: Potassium-(S)-lactate
- Trade name: PURASAL® HiPure P
- Batch No.:1906000138
- CAS No.: 85895-78-9
- EC number: 288-752-8
- Molecular weight: 128 g/mol
- Content: ~100 %
- Physical state: Light yellow liquid
- Storage conditions: Ambient temperature (10 °C to 30 °C)
- Expiry date: May 30, 2021 - Dissociating properties:
- no
- Conclusions:
- Potassium-S-lactate does not dissociate within the pH range prescribed by OECD test guideline 112.
- Executive summary:
The dissociation constant of he test item was determined according to the European Commission Regulation (EC) No. 2017/735, A.25. and according to the OECD test guideline 112 with the titration method. No measurable dissociation constant has been determined using this method.
Reference
A calculation of the pKavalue was not possible as no half-equivalence point could be determined with the titration method according to guideline OECD 112. It was concluded that the test item did not dissociate in the analyzed pH value ranges (6.4 to 11.6 with titration with NaOH, 6.4 to 2.0 with titration with HCl).
Description of key information
Potassium-(S)-lactate does not dissociate within the pH range prescribed by OECD test guideline 112.
Key value for chemical safety assessment
Additional information
The dissociation constant of the test item was determined according to the European Commission Regulation (EC) No. 2017/735, A.25. and according to the OECD test guideline 112 with the titration method. No measurable dissociation constant has been determined using this method.
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