Fatty acids, lanolin, lithium salts

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

12 April - 21 May 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point/Boiling Range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Remarks:

Initially assessed by the Siwoloboff method

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: SOAP012-2
- Expiration date of the lot/batch: 1 November 2022

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Ambient

Decomposition:

yes

Decomp. temp.:

>= 266 °C

Remarks on result:

not determinable

As the boiling tube was heated at 10°C/minute, the sample was observed to darken at temperatures above approximately 266°C and there was an expansion of the material with a bubble formed at the base, indicating decomposition. When heating was continued beyond this temperature to 400°C, the sample continued to darken significantly and there was a greater frequency of foaming. At the end of the visual assessment the material was dark brown/black with a pale brown liquid at the base.

The resulting profile by DSC shows the melting endotherm at approximately 200°C and the onset of decomposition at approximately 300°C. During the DSC assessment, the test item was initially described as an amber crystalline solid and following the measurement the material had turned into a black swollen mass which had extruded out of the crucible.

Conclusions:

The boiling temperature of the test item, fatty acids lanolin lithium salts was not determinable as the test item decomposed at temperatures above approximately 266°C.

Executive summary:

The boiling point of the test item, fatty acids lanolin lithium salts, was assessed in an experimental study conducted according to OECD guideline 103 (Dunning 2018). The boiling temperature is defined as the temperature at which the pressure of the saturated vapour of a liquid is equal to the standard pressure. The boiling temperature was initially assessed by the Siwoloboff method using a calibrated digital melting point apparatus. Due to visual signs of decomposition, the test item was also assessed by differential scanning calorimetry (DSC).

The boiling temperature of the test item was not determinable as the test item decomposed at temperatures above approximately 266°C.

The study is GLP-compliant and was conducted according to the standard guideline, therefore is considered reliable without restrictions and suitable as a key study for this endpoint.

Description of key information

The test item decomposed at temperatures above approximately 266°C.

Additional information

The boiling point of the test item was determined in an experimental study conducted according to OECD guideline 103 (Dunning 2018). The boiling temperature was initially assessed by the Siwoloboff method using a calibrated digital melting point apparatus. Due to visual signs of decomposition, the test item was also assessed by differential scanning calorimetry (DSC).

The boiling temperature of the test item was not determinable as the test item decomposed at temperatures above approximately 266°C.

The study is GLP-compliant and was conducted according to the standard guideline, therefore is considered reliable without restrictions and suitable as a key study for this endpoint.