Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 266-605-9 | CAS number: 67219-55-0
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Conclusion on classification
Two study reports (rated as Klimisch 1) on aquatic organisms are available covering two trophic levels: a primary producer (freshwater algae, represented by the model species Pseudokirchneriella subcapitata) and a primary consumer (aquatic invertebrates, represented by the model species Daphnia magna).
The freshwater algae P. subcapitata was exposed to N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine for 72 hours in a GLP toxicity study (OECD 201) at a limit concentration of 0.117 mg/L (measured, limit of water solubility, loading 100 mg/L nominal). No effect on P. subcapitata was observed.
D. magna was exposed for 48 hours to N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine in a static short-term GLP toxicity study (OECD 202) at measured concentrations of 0.112, 0.225, 0.331, 0.561, and 1.225 mg/L (measured geom. mean). In this study a NOEC of 0.112 mg/L and an EC50 of 0.612 mg/L were derived. The test concentrations were evaluated analytically by HPLC-UV.
Considering that N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine is not readily biodegradable based on ThCO2 (Flach 2018), and the lowest effect value was determined to be < 1 mg/L (EC50 = 0.612 mg/L), N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine has to be classified as “Aquatic Acute 1” (H400) and "Aquatic Chronic 1" (H410) following the provisions laid down in the CLP Regulation (Regulation (EC) No 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
