2-anilinoethanol

Repeated dose toxicity: other routes

Administrative data

Endpoint:

short-term repeated dose toxicity: other route

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Data published in peer reviewed literature, insufficient experimental details given and limited information reported.

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1942

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Two dogs per dose were exposed to the test substance subcutanously. Documentation of clinical signs, haematology and methemoglobin concentrations was performed of the 28-day study period.

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-anilinoethanol

EC Number:

204-588-1

EC Name:

2-anilinoethanol

Cas Number:

122-98-5

Molecular formula:

C8H11NO

IUPAC Name:

2-(phenylamino)ethan-1-ol

Details on test material:

- Name of test material (as cited in article): 2-anilinoethanol

Test animals

Species:

dog

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Diet: commercial chow

Administration / exposure

Route of administration:

subcutaneous

Vehicle:

not specified

Duration of treatment / exposure:

Single injections

Frequency of treatment:

1 to 2 day intervals

Doses / concentrations

Remarks:

Doses / Concentrations:
110, 220 mg/kg

No. of animals per sex per dose:

2

Control animals:

no

Examinations

Other examinations:

- Haematology
- Methemoglobin determined with a Klett-Summerson photoelectric colorimeter.

Results and discussion

Results of examinations

Details on results:

- Two animals treated repeatedly with 110 mg/kg showed no change of the granulocytes or mononuclear with cells, either in numbers or in structure. In one of these animals the hemoglobin dropped form 14 Gm. to 6.3 Gm. per hunderd cubic cm in a 10-day period. By the 27th day the hemoglobin of the first animals had returened to 10.5 Gm. and that of the second to 11 Gm per hunderd cubic cm on the 24th day.
- In an animal given 220 mg/kg severe anemia developed (7.5 Gm. hemoglobin per hunderd cubic cm of blodd) by the 17th day.
- The 4th animal, which died 4 days after treatment, showed a fall in hemoglobin from 11 to 8 Gm. per hunderd cubic cm and the erythrocyte count from 4.8 to 2.5 million per cubic mm shortly before death.
- The red cell count fell uniformly in all 4 animals, but only the last of these animals showed a drop corresponding to the low hemoglobin. There was a slight increase in the number of red cells. No increase in reticulocytes could be demonstrated on the 15th day.

Target system / organ toxicity

Critical effects observed:

not specified