Registration Dossier
Registration Dossier
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EC number: 204-588-1 | CAS number: 122-98-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP non-guideline, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- according to BASF-internal method
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-anilinoethanol
- EC Number:
- 204-588-1
- EC Name:
- 2-anilinoethanol
- Cas Number:
- 122-98-5
- Molecular formula:
- C8H11NO
- IUPAC Name:
- 2-(phenylamino)ethan-1-ol
- Details on test material:
- - Name of the test substance used in the study report: Mono-oxaethylanilin
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- An application site of 2.5x2.5 was covered with the liquid.
- Duration of treatment / exposure:
- - back: 1, 5, 15 min and 20 h
- Observation period:
- 8 days
- Number of animals:
- 2 per exposure duration
- Details on study design:
- TEST SITE
- Area of exposure: back
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- other: 20 hours exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 0
- Max. score:
- 3
- Remarks on result:
- other: 20 hours exposure
- Irritant / corrosive response data:
- - No effects observed in animals exposed for 1, 5 or 15 minutes, on the back.
- Questionable redness observed in one animal exposed for 20 h on the back.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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