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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data id from peer-reviewed journal.

Data source

Reference
Reference Type:
publication
Title:
Monographs On Fragrance Raw Materials: Butyl phenylacetate.
Author:
D.L.J Opydke
Year:
1983
Bibliographic source:
Food and Chemical Toxicology Volume (issue)/page/year: 21, 657, 1983

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Acute dermal toxicity test in Rabbit
Principles of method if other than guideline:
Acute dermal toxicity of Butyl phenylacetate on rabbit.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Butyl phenylacetate
EC Number:
204-543-6
EC Name:
Butyl phenylacetate
Cas Number:
122-43-0
Molecular formula:
C12H16O2
IUPAC Name:
Butyl phenylacetate
Test material form:
liquid
Details on test material:
- Name of test material (IUPAC name): butyl 2-phenylacetate
- Common name: Butyl phenylacetate
- Molecular formula: C12H16O2
- Molecular weight: 192.256 g/mol
- Smiles notation: c1(CC(OCCCC)=O)ccccc1
- InChl: 1S/C12H16O2/c1-2-3-9-14-12(13)10-11-7-5-4-6-8-11/h4-8H,2-3,9-10H2,1H3
- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report): Butyl phenylacetate
- Molecular formula : C12H16O2
- Molecular weight : 192.256 g/mol
- Substance type: Organic
- Physical state: Liquid
- Purity : No data
- Impurities (identity and concentrations): No data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
No data
Duration of exposure:
No data
Doses:
>5000 gm/kg
No. of animals per sex per dose:
No data
Control animals:
not specified
Details on study design:
No data
Statistics:
No data

Results and discussion

Preliminary study:
No data
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality was observed
Mortality:
No mortality was observed
Clinical signs:
other: No data
Gross pathology:
No data
Other findings:
Details of toxic effects not reported other than lethal dose value.

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
LD50 was considered to be >5000mg/kg bw. When rabbits were treated with Butyl phenylacetate by dermal application.
Executive summary:

In Acute Dermal toxicity test, Butyl phenylacetate(122-43-0) was administered onto the skin of rodent rat, at dose concentration of >5000mg/kg, No mortality was observed.Hence, LD50 was considered to be >5000mg/kg bw. When rabbits  were treated with Butyl phenylacetate by dermal application.