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EC number: 821-749-7
CAS number: 154581-97-2
accordance to OECD guideline 438 and GLP the test substance was examined
for its in vitro eye irritating potential using the Isolated Chicken Eye
(ICE) Test. In the ICE test, 3 eyes were exposed to 30 µL test substance
for 10 seconds. In addition, one negative control eye (30 µL saline) and
three positive control eyes (30 µL Benzalkonium Chloride (BAC)) were
tested. After the exposure the eyes were rinsed with 20 mL saline and
were examined at approximately 0, 30, 75, 120, 180, and 240 minutes
after treatment. The test
substance caused corneal effects consisting of very slight corneal
swelling (mean of 1%), slight opacity (mean score of 1.0) and very
slight fluorescein retention (mean score of 0.5). The negative control
eye did not show any corneal effect and demonstrated that the general
conditions during the tests were adequate. The positive control BAC 5%
caused severe corneal effects and demonstrated the ICE test valid to
detect severe eye irritants. Microscopic examination of the corneas
treated with the test substance did not reveal any abnormalities.
Microscopic examination of the cornea treated with the negative control
(saline) did not reveal any abnormalities. Microscopic examination of
the corneas treated with the positive control BAC 5% revealed severe
erosion and very slight vacuolation of the epithelium, the epithelium
partly detached from the basement membrane, and endothelial necrosis. Based
on these results, the test substance is considered to be not eye
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