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EC number: 821-749-7
CAS number: 154581-97-2
There was a statistically significant (p<0.01) difference between the
inter-experimental SI. This is because a higher than average SI was
determined in Test 4. There was also a steeper shape in the
dose-response curve for the Test no. 4 data making it a p<0.01 for the
quadratic component. Both significant differences were lost when data
from Test 4 were excluded from the analysis. The results from Test 4 are
considered be outliers.
Table 1. EC values derived:
Hexyl cinnamaldehyde is recommended as a positive control by the OECD
guideline 406 for Skin Sensitisation. As such, the response of hexyl
cinnamaldehyde in the Local Lymph Node Assay from five different
experiments conducted in a single laboratory over a 10 month period was
analysed. Hexylcinnamaldehyde in 0, 2.5, 5, 10, 25, 50% w/v in 4:1
acetone/olive oil was administered onto the dorsal ears of mice
following a protocol equivalent to the OECD guideline 429 Skin
Sensitisation: Local Lymph Node Assay adopted later. Hexyl
cinnamaldehyde induced a positive response in all five tests (SI>3). The
pooled stimulation indices were used to calculate the EC3 values using
three different statistical approaches (Linear interpolation, Quadratic
regression and Richard's model) which resulted in comparable EC3 values.
Excluding the results of one of the tests which was considered to be an
outlier, the EC3 range for hexylcinnamaldehyde was 6.6 -11.5% under the
conditions of these experiments.
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