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EC number: 821-749-7
CAS number: 154581-97-2
Individual Body weights and Weekly Body weight changes:
Animal Number and Sex
Body weight (g) at Day
Body weight gain (g) during week
A study was performed to assess the acute
oral toxicity of the substance, in accordance with OECD 423 (Acute Oral
Toxicity - Acute Toxic Class Method) and GLP principles. In this study,
6 female rats were administered the substance, orally by gavage,
undiluted at a dose level of 2000 mg/kg bw. The rats showed no
mortality, there were no signs of systemic toxicity, all animals showed
expected gains in body weight over the study period and no abnormalities
were noted at necropsy.The acute oral
LD50 for the substance in female rats is > 2500 mg/kg bw. According to
the schematic diagram presented in annex 2d of OECD 423 (2001) > 2500
can be derived in case 0 or 1 animal died but > 5000 mg/kg bw can be
derived when no animals died. In absence of mortality the 5000 mg/kg bw
can be selected. This seem somewhat stretched in view of the highest
dose being 2000 mg/kg bw and therefore the value of > 2500 mg/kg bw is
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