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EC number: 208-580-9
CAS number: 533-96-0
MORTALITY: one female dosed with 4000 mg/kg died.
- Time of death: The animal died within 24 hours of administration.
- Number of deaths at each dose: 1/5 females dosed with 4000 mg/kg died.
CLINICAL SIGNS: All the surviving animals gained weight during the
postexposure observation period. The clinical signs of toxicity included
soft stool, hypoactivity, dark-stained urogenital area. The surviving
animals returned to a normal appearance by day 2. Of the females dosed
with 3500mg/kg, 4/5 had soft stool, 1/5 had a dark-stained urogenital
area and 1/5 exhibited hypoactivity, within the first day. Among the
females dosed with 4000 mg/kg, 1/5 had soft stool and 1/5 was hypoactive
during the first day. Among the males dosed with 4500 mg/kg, 1/5 had
soft stool and 1/5 was hypoactive during the first day.
NECROPSY FINDINGS: In the female that died on day 0, a single erosion
was found in the glandular mucosa of the stomach near the pylorus. An
enlarged pelvis was present in the right kidney of a male given 3000
mg/kg, both mandibular lymph nodes were enlarged in a male given 4000
mg/kg, and multiple opaque areas were on the parietal surface of the
spleen in a male and a female given 4000 mg/kg.
POTENTIAL TARGET ORGANS: Not reported.
SEX DIFFERENCES: Not reported.
The no observable adverse effects level (NOAEL) is 4,000 mg/kg in males
and 3,000 mg/kg in females.
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