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EC number: 208-580-9
CAS number: 533-96-0
In the plate incorporation test sodium sesquicarbonate was found to be
negative for genotoxicity for all strains tested both with and without
S9 mix. A negative result in the plate incorporation test was defined as
the absence of a reproducible increase in revertants where at least 5 mg
per plate or the maximum non-inhibitory level has been tested.
Sodium sesquibarbonate gave a tow- to three-fold increase over the
solvent control count in strain TA1538 with metabolic activation, and a
two-fold increase over the solvent control count in TA1538. However,
these increases were not dose-related and therefore were not considered
to demonstrate genotoxicity of the substance.
A study was carried out using a method equivalent to the OECD Testing
Guideline 471 (Bacterial Reverse Mutation Test) to determine the
mutagenicity of 25 cosmetic product ingredients including sodium
sesquicarbonate. Five mutated strains of Salmonella typhimurium (S.
typhimurium LT2 hisTA98, hisTA100, hisTA1535, hisTA1537 and hisTA1538)
were exposed to sodium sesquicarbonate first in a spot test for
screening and subsequently in a plate incorporation test. The test
substance was found to be positive for genotoxicity in the spot test on
TA100 without metabolic activation, however, in the plate incorporation
test sodium sesquicarbonate was found to be negative for genotoxicity
for all strains tested both with and without S9 mix. Positive and
negative controls, along with sterility controls, were conducted and all
were found to be valid.
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