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EC number: 208-580-9
CAS number: 533-96-0
The substance will quickly dissociate to sodium and carbonate ions in biological systems. Local irritation to respiratory tract may be felt and ingestion of large quantities may result in production of CO2 in contact with stomach acids. These are not considered to be toxic effects.
The human information on acute toxicity of sodium bicarbonate has
been described already on page 14 and 15 of the OECD SIDS dossier
(2002). Please find hereafter the text:
There have been a number of cases where excessive ingestion has caused
moderate to severe toxic effects. The most prevalent symptoms are
excessive carbon dioxide production, metabolic alkalosis, cyanosis,
hypernatraemia and diuresis (Brown, 1981; AMA, 1994). Although
absorption of unneutralised NaHCO3is known to cause alkalosis
(Goodman and Gilman, 1995), this acid-base disturbance is usually
transient in individuals with normal renal function, as the base excess
will rapidly be excreted. The urinary pH can, however, be elevated by up
to 1 unit, affecting tubular reabsorption and urinary elimination of
weak acids and bases (Goodman and Gilman, 1995). The minimum dose
causing adverse effects will vary strongly according to age and health
condition, but for antacid use it is inadvisable to ingest more than 4
grams/dose (Gosselin, 1976).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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