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EC number: 250-705-4
CAS number: 31566-31-1
NOEC (14 d) ≥ 1000 mg/kg dw for Eisenia fetida (OECD 207)
No experimental data evaluating the toxicity Stearic acid,
monoester with glycerol (CAS No. 31566 -31 -1) to soil macroorganisms
are available. Therefore, in accordance to Regulation (EC) No. 1907/2006
Annex XI, 1.5 Grouping of substances, a read-across to the structurally
related category members Glycerides, C14-18 and C16-18 unsaturated,
mono-, di- and tri- (CAS No. No. 91052-28-7) was conducted. Further
justification is given within the endpoint summary 6.1 and 6.3 within
the category justification section 13. In this case of read-across, the
best suited (highest degree of structural similarity, nearest
physico-chemical properties) read-across substance within this category
The toxicity of Glycerides, C14-18 and C16-18 unsaturated, mono-,
di- and tri- (CAS No. 91052-28-7) to earthworms was evaluated by Moser
(2013). Eisenia fetida was exposed to the test substance for 14 days at
a concentration of 1000 mg/kg dw (limit test). Due to the poor
solubility of the substance in water, test solutions were prepared using
a solvent. No effects on survival or biomass during the exposure period
were reported, leading to a NOEC (14 d) ≥ 1000 mg/kg dw.
Stearic acid, monoester with glycerol (CAS No. 31566 -31 -1) is
readily biodegradable. Therefore, rapid and ultimate degradation in the
environment, including soil, can be expected. Chronic exposure of
terrestrial organisms is thus very unlikely. Furthermore, this substance
shows only low toxicity, if at all, to aquatic organisms. Due to the
metabolization via enzymatic hydrolysis of the Glycerides category
members, a relevant uptake and bioaccumulation in biota is not expected.
Enzymatic breakdown will initially lead to the free fatty acid and
glycerol. Glycerides are naturally stored by organisms as long-term
energy reserves. Especially in periods in which the energy demand is
high (reproduction, migration, etc.), glycerides are mobilized from the
storage sites as source of fatty acids. Fatty acid catabolism is the
most important energy source in many species, resulting in the release
of acetyl CoA and NADH (through β-oxidation) and eventually, via the
tricarboxylic cycle, the production of metabolic energy in the form of
ATP. Please, refer to IUCLID Section 5.3.1 for a detailed overview on
bioaccumulation of the Glycerides category members.
Based on the results obtained for the structurally related
analogue (in accordance with Regulation (EC) No. 1907/2006, Annex XI,
1.5) and the characteristics of the substance, Stearic acid, monoester
with glycerol (CAS No. 31566 -31 -1) is not expected to show toxicity to
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