Registration Dossier
Registration Dossier
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EC number: 284-965-5 | CAS number: 85005-32-9
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Read-across from an analogue substance for which a guideline study (Klimish =1) is available.
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
See attached reporting format. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOELR
- Remarks:
- No observed effect loading rate
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Based on the read-across approach from an analogue substance.
- Conclusions:
- Based on the read-across from an analogue substance, the No Observed Effect Loading Rate of the target substance is 100 mg/l loading rate WAF for acute (48-hour) toxicity to the freshwater invertebrate Daphnia magna.
- Executive summary:
A study was performed to assess the acute toxicity of an analogue substance to Daphnia magna. The method followed that described in the OECD Guideline 202 and was conducted in accordance with GLP standards. The 48-Hour EL50(Effective Loading rate) for the test item to Daphnia magna based on nominal loading rates was greater than 100 mg/l loading rate WAF and correspondingly the No Observed Effect Loading Rate was 100 mg/l loading rate WAF. Based on the read-across approach, the 48h- NOELR of the target substance is 100 mg/L loading rate WAF.
Reference
Description of key information
Key study: Test method according to OECD 202. GLP study. Based on the read-across from an analogue substance, the 48 h-EC50 is greater than 100 mg/L loading rate WAF and the 48h-NOELR is 100 mg/L loading rate WAF.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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