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EC number: 700-158-7
CAS number: 1092834-40-6
3-minute and 1-hour semi occluded
applications of the test material to the intact skin of the first rabbit
produced no evidence of skin irritation.
A single 4-hour, semi-occluded application
of the test material to the intact skin of two rabbits produced no
evidence of skin irritation.
All animals showed expected gain in
bodyweight during the study.
Table 1: Individual skin examination
scores after 4h-exposure to SH-1
(Scoring according to Draize scheme)
Animal No. /sex
#1 / m
#2 / m
aTimepoint of reading after
substance removal subsequent to 4h-dermal exposure
bMean of 24, 48 and 72 h scores
In a primary dermal irritation study, the
skin irritation/corrosion potential of Benzene,
1,1'-(1,2-ethanediyl)bis-, brominated was tested. The clipped
dorso-lateral skin of two male New Zealand White rabbits was exposed to
0.5 mg test material in 0.5 mL distilled water for 4 hours under
semi-occlusive conditions. The rabbits were observed for 72 hours. Skin
reactions were assessed using the Draize scheme 1, 24, 48 and 72 hours
after removal of the test substance.
The exposure period of up to 4 hours
produced no evidence of skin irritation at any of the observation
Based on the study results, the test
substance is non-irritating to the skin of rabbits and therefore not
classified according to EU classification and OECD GHS classification
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