Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Corrosive to skin and eye based on free acetic acid content.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vitro / ex vivo
Data waiving:
other justification
Justification for data waiving:
other:
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vitro / ex vivo
Data waiving:
other justification
Justification for data waiving:
other:
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

The registered substance is a multi-constituent substance which includes acetic acid at ca. 36% (w/w). Acetic acid (CAS 64-19-7) is classified as corrosive to skin and eye according to Annex VI of Regulation (EC) No 1272/2008 (Skin Corr. 1A; H314). Taking into account the content of free acetic acid and the specific concentration limits for acetic acid concerning corrosive properties, the registered substance is assessed to be corrosive to skin and eyes.

The publication of Björnberg A. and Mobacken H. (1972) described a test on skin irritation/corrosion properties of the test substance. Guinea pigs were used as a test model. Five animals were first shaved with an electrical razor. Then the skin on the side of the body was stripped vertically. The test substance in a saturated solution (concentration 2 %) was applied horizontally on the stripped skin. For control, two areas were stripped but no substance was applied and two areas were not stripped and substance was applied. Application was repeated daily for three consecutive days. Skin biopsies were taken 72 h after beginning of the experiment.

After treatment of shaved and stripped skin of guinea pigs a reaction to a 2 % concentration of the test substance was observed. The epidermal structure was disrupted and inflammatory infiltrates into the dermis were observed. Application on skin areas that were shaved but not stripped led to a slight inflammatory response.


Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Justification for classification or non-classification

The registered substance is a multi-constituent substance which contains acetic acid at ca. 36%. Acetic acid (CAS 64-19-7) is classified as corrosive to skin and eye according to Annex VI of Regulation (EC) No 1272/2008 (Skin Corr. 1A; H314). Taking into account the specific concentration limits for acetic acid, classification of the registered substance with Skin Corr. 1B; H314 is warranted under Regulation (EC) No 1272/2008 (SCL: 25% ≤ C < 90%).