Registration Dossier
Registration Dossier
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EC number: 419-710-0 | CAS number: 42774-15-2
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Remarks:
- other: Short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, B.7; OECD 407
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- N,N'-bis(2,2,6,6-tetramethyl-4-piperidyl)isophthalamide
- EC Number:
- 419-710-0
- EC Name:
- N,N'-bis(2,2,6,6-tetramethyl-4-piperidyl)isophthalamide
- Cas Number:
- 42774-15-2
- Molecular formula:
- C26H42N4O2
- IUPAC Name:
- N,N'-bis(2,2,6,6-tetramethyl-4-piperidyl)isophthalamide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- other: rat, Sprague-Dawley
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: 1 % wässrige Carboxymethylcelluloselösung
- Details on oral exposure:
- Method of administration:
Magensonde - Duration of treatment / exposure:
- Test duration: 28 days
- Frequency of treatment:
- Dosing regime: 7 days/week
- No. of animals per sex per dose:
- Male: 5 animals at 0 mg/kg bw/day
Male: 5 animals at 50 mg/kg bw/day
Male: 5 animals at 150 mg/kg bw/day
Male: 5 animals at 500 mg/kg bw/day
Female: 5 animals at 0 mg/kg bw/day
Female: 5 animals at 50 mg/kg bw/day
Female: 5 animals at 150 mg/kg bw/day
Female: 5 animals at 500 mg/kg bw/day
Results and discussion
Results of examinations
- Details on results:
- Clinical observations:
There were no treatment-related deaths.
Substance-induced effects on body weight gain,
Food or water consumption were not observed.
Laboratory findings:
In the high dose were in the males a
Lowering of the erythrocyte cell number and an increase in the
central blood volume diagnosed. Clinical-chemical
was in the males in the medium dosage,
seen increased activity of ASAT. Investigations
Urine showed no treatment-related effects.
Effects in the institution:
Macroscopic and histomorphological investigations
There were no findings on substance-induced functional
or morphological changes in both sexes.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 500 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCD unit is mg/kg/day.
- Dose descriptor:
- NOAEL
- Effect level:
- 50 mg/kg bw/day (nominal)
- Basis for effect level:
- other: original NCD unit is mg/kg/day.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Classified as: Not classified
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