Registration Dossier
Registration Dossier
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EC number: 419-710-0 | CAS number: 42774-15-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OCDE n° 401 (1987) Directive CEE 92/69 (1992) - annexe V - méthode B1
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N,N'-bis(2,2,6,6-tetramethyl-4-piperidyl)isophthalamide
- EC Number:
- 419-710-0
- EC Name:
- N,N'-bis(2,2,6,6-tetramethyl-4-piperidyl)isophthalamide
- Cas Number:
- 42774-15-2
- Molecular formula:
- C26H42N4O2
- IUPAC Name:
- N,N'-bis(2,2,6,6-tetramethyl-4-piperidyl)isophthalamide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- other: Rat Sprague-Dawley
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: An aqueous dispersion of 1% carboxymethylcellulose
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 258 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 069 - 1 480
- Mortality:
- Male: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 1260 mg/kg bw; Number of animals: 5; Number of deaths: 3
Male: 1590 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 3
Female: 1260 mg/kg bw; Number of animals: 5; Number of deaths: 1
Female: 1590 mg/kg bw; Number of animals: 5; Number of deaths: 4 - Clinical signs:
- Signs of toxicity related to dose levels:
Clinical signs appeared in treated animals
one hour after administration. Lethargy, prostration,
depression and tremors were observed up to 4 hours
after treatment. - Gross pathology:
- Effects on organs:
No
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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