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EC number: 500-148-0
CAS number: 61788-89-4
If a substance has a low potential for bioaccumulation and/or a low
potential to cross biological membranes, or if direct and indirect
exposure of the aquatic compartment is unlikely, then in accordance with
Regulation (EC) No 1907/2006, Annex IX, 9.3.2, column 2, studies on
bioaccumulation are not required. This is the case for the dimerised
fatty acids and their derivatives, and in this particular case for Fatty
acids, C18-unsaturated, dimers (CAS No. 61788-89-4).
Due to the potential of these
substances to adsorb, one may assume that the uptake may occur through
the ingestion of soil or sediment. However, uptake of dimers and trimers
is expected to be low based on the fact that the dimerised fatty acids
are relatively large molecules (C16-18 as monomers, C36 as dimers and
C54 as trimers) with high molecular weights (dimeric acids 561 g/mol,
trimeric acids 838 g/mol). Thus, according to Lipinski’s rule of five
(Lipinski et al., 2001), they have a low potential to cross biological
Additionally, from the toxicokinetic behaviour of mono- and oligomeric
fatty acids in mammals it can be assumed that unsaturated monomeric
C16-C18 fatty acids are more readily absorbed than saturated fatty acids
like octadecanoic and isooctadecanoic acid, but less readily than fatty
acids with shorter chain length. Very low absorption is reported for
dimeric and trimeric fatty acids via the gastro intestinal tract and
thus, most of the ingested fatty acids will be excreted in the faeces (≥
80 % for dimeric acid methyl esters (Hsieh and Perkins, 1976; Paschke et
al. 1964)). In case of absorption fatty acids will undergo rapid
metabolisation and excretion (either in the expired CO2 or as
hydroxylated or conjugated metabolite in the urine in the case of cyclic
fatty acids) as they feed into physiological pathways like the citric
acid cycle, sugar synthesis, and lipid synthesis.
As fatty acids are naturally stored in the form of triacylglycerols
primarily within fat tissue until they are used for energy production
(fat storage tactic), it is therefore concluded that there will be no
risk to organisms from bioconcentration/biomagnification of fatty acids
within the food chain.
Finally, dimerised fatty acids have a very low water solubility
(subcategory dimers and trimers: all < 0.52 mg/L), therefore only low
concentrations in the aquatic environment and thus low concentrations in
aquatic organisms can be expected, if at all.
Hence, Fatty acids, C18-unsaturated, dimers (CAS No. 61788-89-4) does
not pose a risk to organisms with regard to
Lipinski et al. (2001) Experimental and computational approaches to
estimate solubility and permeability in drug discovery and development
settings, Adv. Drug Del. Rev., 2001, 46, 3-26
Hsieh, A. and Perkins, E.G. (1976). Nutrition and Metabolic Studies of
Methyl Ester of Dimer Fatty Acids in the Rat. Lipids, 11(10):763-768.
Paschke, R.F. et al. (1964). Dimer acid structures. The dehydro-dimer
from methyl oleate and Di-t-butyl peroxide. Journal of the American Oil
Chemists' Society 41(1):56-60.
U.S.Environmental Protection Agency (2009). Risk-Based Prioritization
Document. Initial Risk-Based Prioritization of High Production Volume
(HPV) Chemicals – Fatty Acid Dimers and Trimer Category. pp 1-19. Report
date: April 2009.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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