Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Die akute und chronische Toxizität der Ameisensäure und ihrer Formiate.
Author:
Malorny G
Year:
1969
Bibliographic source:
Zeitschrift Ernährungswissenschaft 9, 332-339.

Materials and methods

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Potassium formate
EC Number:
209-677-9
EC Name:
Potassium formate
Cas Number:
590-29-4
Molecular formula:
CH2O2.K
IUPAC Name:
potassium formate
Details on test material:
TS-Freetext:
Potassium formate; purity not reported.
Specific details on test material used for the study:
Potassium formate; purity not reported.

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intravenous
No. of animals per sex per dose:
55

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
95 mg/kg bw

Any other information on results incl. tables

RS-Freetext:
LD50 of formic acid and its salts in the mouse following
i.v. injection:

===========================================================
Substance      LD50      range        LD50           No. of
                                    (formate #)     animals
                 (mg/kg bw)         (mg/kg bw)          n
-----------------------------------------------------------
Formic acid    145      138-151        142             50
Na-formate     807      800-813        534             50
K-formate       95       93-97          51             55
NH4-formate    410      408-412        293             50
Ca-formate     154      150-158        107             55 
===========================================================
# = calculated proportion of formate of the LD50 dose.

Applicant's summary and conclusion

Conclusions:
The LD50 of potassium formate was 95 mg/kg bw in mice following i.v. injection.