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EC number: 204-634-0
CAS number: 123-54-6
A 4 hour application of 0.5 ml of
Acetylacetone (2,4 -Pentanedione) was applied on 3 male and 3 female New
Zealand White rabbits dosed with 0.5 ml. The dose is applied to a
clipped, intact skin under a gauze patch and is loosely covered with
impervious sheeting. Smaller amounts are given if 0.5 ml is lethal. The
test material was applied to each of 6 rabbits which are restrained for
the 4 hr contact period. Excess sample is removed after contact. Skin
reaction were scored by the method of Draize at one hour, one day, 2
days, 3 days 7 days and depending on the local skin reaction possibly 14
days after dosing.
One hour after removal of the occlusive
dressing slight erythema detectable in 5/6 animals; after 24 hours
erythema detectable in 6/6 animals; moderate edema formation observable
in 1/6 rabbits and slight edema formation in 5/6 rabbits one hour after
removal of the occlusive dressing; after 24 hours slight edema still
present in 5/6 rabbits. After 48 and 72 hours five and three animals
revealed just detectable erythema, respectively; Mild edema were
observable at 48 and 72 hours in two and one animals, respectively. With
the exception of mild desquamation no effects on day 7. Other
irritations or effects were not detectable at any observation time.
Acetylacetone has not to be classified according to the slight reactions
observed under the conditions used.
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