Registration Dossier
Registration Dossier
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EC number: 204-634-0 | CAS number: 123-54-6
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- up to 1985
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Due to both the poor description of the study and the very weak irritating potential of the compound a verification of the results described is lacking.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Twelve control persons were testes with 100 % test substance in a patch test. .
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Pentane-2,4-dione
- EC Number:
- 204-634-0
- EC Name:
- Pentane-2,4-dione
- Cas Number:
- 123-54-6
- Molecular formula:
- C5H8O2
- IUPAC Name:
- pentane-2,4-dione
- Details on test material:
- not reported
Constituent 1
Method
- Type of population:
- not specified
- Ethical approval:
- not specified
- Subjects:
- Twelve control persons were testes with 100 % test substance. Gender, health status and possible allergic predispositions of test persons
not specified. - Clinical history:
- not specified
- Controls:
- no data
- Route of administration:
- dermal
- Details on study design:
- Twelve control persons were testes with 100 % test substance.
TYPE OF TEST(S) USED: patch test (epicutaneous test)
Results and discussion
- Results of examinations:
- Three/12 persons showed no, 7/12 doubtful and 2/12 positive reaction to the test substance after 24 h, but not after 48 and 72 hours, respectively. The reactions observed were assessed to be possibly irritating but not sensitizing effects and it was concluded that sensitization might occur more frequently due to prolonged and close skin contact of pads containing the
substance. A clear cut explanation for the observations made was not given.
Applicant's summary and conclusion
- Conclusions:
- Due to both the poor description of the study and the very weak irritating potential of the compound a verification of the results described is lacking.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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