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EC number: 204-528-4
CAS number: 122-20-3
With high probability long-term effects on fish are not expected (NOEC
>= 10 mg/L).
The long-term effects of the substance on early-life stages of Danio
rerio were investigated in GLP study following OECD TG 210 (Isopropanol
Amines Consortium, 2022; report no. S21-05543).
A range finder showing no adverse effects at the highest test
concentration of 10 mg/L was done beforehand. As no adverse effects
occured, the final test was conducted as an extended limit test in
accordance with OECD guideline 210, section 22.
The test was conducted under flow-through conditions with nominal
concentrations of 1.00, 3.16 and 10.0 mg/L and control with an exchange
rate of six times per 24 hours. The test item concentrations were
analytically verified and proved to be stable within acceptable limits;
therefore, the effect values are expressed as nominal concentrations.
The validity criteria of the guideline were met. The study is valid.
Fertilised eggs were exposed to the substance. Hatchability, post-hatch
survival, cumulative mortality as well as length and weight (fresh and
dry) were evaluated. In addition, the behaviour of the hatched larvae
was observed. No statistically significant effects on any endpoint were
seen at any test concentration. The LOEC values are > 10.0
mg/L (nominal). The NOEC was observed at >= 10.0 mg/L (nominal).
It can be concluded that with high probability long-term effects on fish
are not expected (NOEC >= 10 mg/L).
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