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EC number: 629-765-4
CAS number: 1226892-44-9
of Contact Hypersensitivity to Tall oil diethylenetriamine imidazoline
in the Albino Guinea Pig( Maximization Test).
The study was carried out based on the
guidelines described in:
OECD No. 406 (1992) "Skin
EC No 440/2008; B6: "Skin
Sensitization: Guinea-Pig Maximization Test (GPMT)"
EPA OPPTS 870.2600 (2003) “Skin
JMAFF Guidelines (2000) including the
most recent partial revisions.
The study was based on the method
described by Magnusson and Kligman, "Allergic Contact Dermatitis in the
Guinea Pig - Identification of Contact Allergens" (1970).
Test substance concentrations selected
for the main study were based on the results of a preliminary study.
In the main study, ten experimental
animals were intradermally injected with a 0.1% concentration and
epidermally exposed to a 0.5% concentration. Five control animals were
similarly treated, but with vehicle alone (corn oil).
Two weeks after the epidermal
application all animals were challenged with a 0.5% test substance
concentration and the vehicle.
Skin reactions of grade 1 were
observed in four experimental animals in response to the 0.5% test
substance concentration. No skin reactions were evident in the control
The skin reactions observed in
response to a 0.5% test substance concentration in 4 (of the ten)
experimental animals in the challenge phase were considered indicative
of sensitization, based on the absence of any response in the control
animals. These results indicate a sensitization rate of 40 per cent.
The results lead to classification according
to CLP (ATP 2): Skin sensitiser Cat.1A (GPMT = 30% positive at = 0.1%
As explained in the category
justification, For cross-reading in general use is made with data of
same or lower EA-length where available, and that of Tall oil + DETA
representing the worst case.
This dossier is for the substance
"Fatty acids C18 unsat, reaction products with triethylenetetramine" (or
TO + TETA). As for the substance itself no toxicological information is
available, cross-reading has been applied to TO + DETA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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