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EC number: 629-765-4
CAS number: 1226892-44-9
Assessment of acute oral toxicity with Tall
oil diethylenetriamine imidazoline in the rat (Acute Toxic Class
The study was carried out based on the
guidelines described in:
OECD No.423 (2001) "Acute Oral Toxicity,
Acute Toxic Class Method"
Commission Regulation (EC) No 440/2008, B1
tris: "Acute Oral Toxicity, Acute Toxic Class Method"
EPA, OPPTS 870.1100 (2002), "Acute Oral
JMAFF guidelines (2000) including the most
recent partial revisions.
Initially, Tall oil diethylenetriamine
imidazoline was administered by oral gavage to three female Wistar rats
at 300 mg/kg body weight. In a stepwise procedure additional groups of
females were dosed at 300 and 2000 mg/kg body weight. All animals were
subjected to daily observations and weekly determination of body weight.
Macroscopic examination was performed on the day of death or after
terminal sacrifice (Day 15).
One female at 2000 mg/kg was found dead on
Day 4. No (further) mortality occurred at 300 and 2000 mg/kg.
Clinical signs observed during the study
period were as follows:
Hunched posture, piloerection, lethargy,
uncoordinated movements, rales, lean appearance and/or ptosis between
Days 1 and 2; one female showed hunched posture and rales throughout the
observation period, along with lean appearance and piloerection on Day
Hunched posture, piloerection and/or
lethargy between Days 1 and 5.
One female at 300 mg/kg showed body weight
loss throughout the observation period. Other animals at 300 mg/kg
showed normal body weight gain.
One female at 2000 mg/kg found dead on Day 4
showed body weight loss between Days 1 and 4. Three other females at
2000 mg/kg showed no body weight gain or slight body weight loss between
Days 1 and 8. Body weight gain among the (other) surviving females at
2000 mg/kg during the (remainder of the) observation period was
considered to be normal.
One female at 300 mg/kg showed gaseous
distension of the gastro-intestinal tract. No further macroscopic
abnormalities were noted among other animals at 300 mg/kg.
Three females at 2000 mg/kg showed a stomach
and right lateral lobe of the liver grown together with the diaphragm.
No macroscopic abnormalities were noted in the other animals at 2000
mg/kg, including the female found dead on Day 4.
No explanation could be found for the
differing macroscopic findings between the two treated groups at 2000
The oral LD50 value of Tall oil
diethylenetriamine imidazoline in Wistar rats was established to exceed
2000 mg/kg body weight.
According to the OECD 423 test guideline,
the LD50 cut-off value was considered to be 2500 mg/kg body weight.
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