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EC number: 220-562-2
CAS number: 2814-77-9
The primary eye irritation potential of Hansa Rot R was investigated
according to OECD test guideline no. 405. The test item was applied by
instillation of 0.1 g into the left eye of each of three young adult New
Zealand White rabbits. Scoring of irritation effects was performed
approximately 1, 24, 48 and 72 hours after test item instillation. The
mean score was calculated across 3 scoring times (24, 48 and 72 hours
after instillation) for each animal for corneal opacity, iris, redness
and chemosis of the conjunctivae, separately. The individual mean scores
for corneal opacity and iris were 0.00 for all three animals. The
individual mean scores for the conjunctivae were 0.33, 0.00 and 0.33 for
reddening, respectively, and 0.00 for chemosis for all the three
animals. The instillation of Hansa Rot R into the eye resulted in mild,
early-onset and transient ocular changes, such as reddening of the
conjunctivae and sclerae, discharge and chemosis. These effects were
reversible and were no longer evident 48 hours after. Very slight
corneal opacity affecting the whole area was noted in one animal 1 hour
after the instillation. This finding, however, was considered to be
caused by the staining produced by the test item and was no longer
evident at the 24-hour reading. A slight red staining was observed in
all three animals 1 hour after the application and persisted in two
animals up to the 24-hour reading. No corrosion was observed at any of
the measuring intervals and no clinical signs were observed. Thus, the
test item did not induce significant or irreversible damage to the
rabbit eye. .
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