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EC number: 305-795-0
CAS number: 95009-65-7
In a reproductive/developmental toxicity
screening study, 10 rats/sex/group were exposed to Gum Rosin at dose
concentrations of 0, 1000, 3000, or 10000 ppm for 41-45 days (females)
or 30 days (males) in the diet. Treatment with Gum Rosin at 10000 ppm
was associated with reduced weight gain/weight loss and reduced food
consumption in the parental generation and a slight decrease in the mean
number of implantation sites resulting in a subsequent slight reduction
in litter size. Body weight gain reductions were also observed in males
exposed to 3000 ppm Gum Rosin. Adverse effects in the F1 pups were
limited to slightly reduced litter and pup weights. Based on the results
of the present study, the no-observed-effect-level (NOEL)
for reproductive/developmental toxicity in Sprague-Dawley rats was
considered to be 3000 ppm for males and females and the NOEL for
subchronic toxicity was considered to be 1000 ppm in males and 3000 ppm
in females based upon reduced feed consumption and lower weight gain in
animals consuming higher dietary concentrations of the test material.
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