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EC number: 305-795-0
CAS number: 95009-65-7
The LD50 of
the test substance is greater than 2000 mg/kg bw by the dermal route in
male and female rats.
In an acute dermal toxicity study, a group of five male and five female
rats was administered a single dose of Gum Rosin topically, under porous
gauze dressing, at a dose level of 2000 mg/kg bw in a dimethylsulfoxide
vehicle for an exposure period of 24 hours. Under the conditions of this
study, the dermal LD50 of Gum Rosin in male and female Sprague-Dawley
rats was > 2000 mg/kg bw. No mortality was observed in the study and,
after an absence of body weight gain was noted in all males and females
on Day 2, the animals recovered and gained weight normally over the rest
of the study period. No systemic clinical signs related to the
administration of the test substance were observed. Other than a slight
dryness to dryness noted at the treatment site of one or more animals at
various times during the study, there were no signs of irritation,
necrosis, ulceration or evidence of tissue destruction reported. At
necropsy, no gross lesions were observed. Based on the results of this
study, Gum Rosin is not acutely toxic to rats via the dermal route and
therefore is expected to present a low toxicity hazard upon skin contact
under conditions of normal use.
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