Registration Dossier
Registration Dossier
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EC number: 209-090-8 | CAS number: 555-31-7
Endpoint summary
Administrative data
Description of key information
Aluminium tri-isopropanolate dissociates instantaneously when exposed to water forming isopropanol and aluminium(III) species. Therefore the effects of both hydrolysis products are considered most relevant to assess the toxicity of aluminium tri-isopropanolate. Isopropanol is rapidly biodegradable and of low toxicity ( LC/EC50 values ≥ 100 mg/L). For aluminium species acute and long-term studies at three trophic levels are available. The LC50 for acute toxicity in fish has been set at 0.078 mg Al/L based on a weight of evidence approach. In a study on eggs of the brook trout the NOEC for incomplete hatching was 57 µg/L (as total Al). In daphnia magna the lowest EC50 reported was 3.9 mg Al/L. In a long-term daphnia study no effects were found at 1.1 mg Al/L at pH 7.61. The NOEC for growth rate in fresh water species Monoraphidium dybowskii and Stichococcus sp. is is 0.04 mg/L. In salt water micro algae the EC10 for growth rate was 18 µg/L.
The EC50 in pseudomonas putida is 165 mg/L as Al.
Additional information
The lowest NOEC has to be chosen as starting point for the derivation of the PNEC. This value comes from the studies on algae and is 40 µg/L for fresh water and 18 µg/L for marine water.
The WHO limit for good quality surface water (Al < 1.6 ug/L at pH 6.5) (WHO http://www.who.int/water_sanitation_health/resourcesquality/wpcchap2.pdf ) is very close to the PNEC that can be derived based on the data in this dossier and will therefore used as PNEC in a worst case approach.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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