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EC number: 614-523-2
CAS number: 68475-37-6
Endpoint specific guidance (ECHA,
2008) indicates that absorption of substances following exposure by
inhalation, skin contact or ingestion may be predicted based on log Pow
and water solubility. Experimentally determined results for substances
in this category are as follows:
Resin acids and Rosin acids, hydrogenated, Me esters
6.4 – 7.6
Resin acids and rosin acids, esters with glycerol
Resin acids and rosin acids, hydrogenated, esters with glycerol
Resin acids and rosin acids, polymerized, esters with glycerol
Resin acids and rosin acids, esters with ethylene glycol
5.65 - >6.5
Resin acids and rosin acids, esters with diethylene glycol
Resin acids and rosin acids, esters with triethylene glycol
Resin acids and rosin acids, hydrogenated, esters with triethylene glycol
Resin acids and rosin acids, esters with pentaerythritol
Resin acids and rosin acids, hydrogenated, esters with pentaerythritol
Resin acids and rosin acids, polymerized, esters with pentaerythritol
ECHA (2008) indicates that uptake of
substances by the lung and gastrointestinal tract is favoured by
moderate log P values (between -1 and 4) with micellular solubilisation
favoured where log P is >4 and water solubility is low (< 1 mg/l). Data
summarised above suggests that the majority of substances included in
this category may be absorbed if inhaled or ingested, although the
extent of uptake is not clear. A low vapour pressure means that
substances in this category are unlikely to exist as vapour, with
inhalation exposure limited to material deposited as particles.
Dermal absorption of highly water soluble
substance may occur where the log Pow is between 1-4 with log Pow values
between 2 and 3 favouring uptake. When log Pow exceeds 4, penetration
may be limited by the rate of transfer between the stratum corneum and
epidermis although uptake of a substance by the stratum corneum will be
high. Uptake of substances where log Pow exceeds 6 will be low (ECHA,
2008). Based on these criteria, the data summarised above suggests that
members of this category are not likely to penetrate the skin.
Experimental data are also available to
characterise the toxicokinetic behaviour of the glycerol ester member of
The absorption, disposition and excretion of
[C^14]ester gum (Resin acids and rosin acids, esters with glycerol) in
the rat was investigated in an oral study conducted by a method similar
to that found in OECD Guideline 417 (Southern Research Institute, 1996).
Male and female rats were administered a single oral dose of 200 mg/kg
bw of [C^14] ester gum following one or ten days of dietary
administration of the unlabelled compound. The degree of absorption of
ester gum was determined by quantitating the amount of radioactivity
eliminated in expired air, urine and feces over the next 120 hours and
assessing residual radioactivity in the carcasses at study termination.
A separate study investigated the amount of radioactivity excreted in
bile and present in blood at 4 or 12-hour intervals after administration
of a single bolus dose of [C^14]ester gum. Most of the dose (>95%) was
recovered in the feces and cage rinses. Low levels of radioactivity
detected in the carcasses at study termination were thought to be from
fecal material remaining in the gastrointestinal tract which was not
removed prior to analysis of the carcasses. HPLC analysis of fecal and
bile extracts indicated that only a very small percentage of the
administered [C^14]ester gum was hydrolyzed and there was no significant
difference in metabolic profile following one or ten days of dietary
administration of the unlabelled compound. Recoveries in the CO2 traps
and urine were each 1% or less of the administered dose. Low levels of
radioactivity detected in the blood during the first 24 hours after
[C^14]ester gum administration accounted for 0.1% or less of the dose
and radioactivity in livers from these same rats accounted for 0.1-0.2%
of the dose indicating that hepatic retention of radioactivity was
essentially negligible. The results indicate that only a small
percentage of the administered [C^14]ester gum was absorbed from the
gastrointestinal tract, with most of the dose (>95%) recovered in the
feces within the first 48 hours.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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