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EC number: 614-523-2
CAS number: 68475-37-6
The 48-hour EL50 was 27 mg/L for Resin acids and rosin acids, hydrogenated, Me esters. This result is read across to lo molecular weight members of the category.For higher molecular weight category members the EL50 was determined to be greater than the highest loading rate in all studies. The 48-hour EL50 for higher molecular weight category members is determined to be >100 mg/L.
Based on the available ecotoxicity
data, differences in ecotoxicity were observed between low molecular
weight and high molecular weight category members. Therefore, for
environmental classification purposes, data for low molecular weight
substances is used to classify the two low molecular weight esters
(methyl esters) and data for high molecular weight category members is
used to classify higher molecular weight esters.
Low molecular weight substances
A GLP-compliant study following OECD
Guideline 202 was conducted for Resin acids and rosin acids,
hydrogenated, Me esters (Inveresk, 2001c). As the test item is poorly
soluble, testing was conducted using water accommodated fractions. There
was no analytical verification of test concentrations and results are
expressed as nominal loading rates. The EL50 from this study was 27
mg/L. The results from this study are read across to the substance Resin
acids and rosin acids, Me esters for classification purposes.
High molecular weight substances
reliable studies are available for higher molecular weight esters within
this category. Studies are available for Resin acids and rosin acids
esters with glycerol, Resin acids and rosin acids esters with
pentaerythritol and Resin acids and rosin acids esters with ethylene
glycol. All studies are GLP-compliant and followed OECD guideline 202
(Inveresk 2001d; Harlan Laboratories, 2010a and 2014b). The test
solutions were prepared as water accommodated fractions (WAF) in the
studies. For the studies with Resin acids and rosin acids, esters with
glycerol and Resin acids and rosin acids, esters with ethylene glycol
analytical verification of test concentrations was carried out. However,
given that toxicity cannot be attributed to a single component or a
mixture of components but to the test item as a whole the results were
based on nominal loading rates only. The study using Resin acids and
rosin acids, esters with pentaerythritol did not have analytical
verification of test concentrations and results are expressed as nominal
loading rates. In all
studies the EL50 was determined to be greater than the highest
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