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EC number: 614-523-2
CAS number: 68475-37-6
data is being read across from the source study that tested Resin acids
and Rosin acids, hydrogenated, methyl esters based on category read
across that is explained in the category justification document attached
in Section 13 of the dossier.
In a human repeated insult patch test
(similar to Modified Draize Procedure), a group of two hundred nine
subjects (males and females) above the age of 16 were repeatedly exposed
to 0.2 gram of Resin acids and Rosin acids, hydrogenated, Me esters
using occluded patches applied to the skin. Induction applications were
made 3 times/week for 3 successive weeks. No skin responses were evident
during the induction phase of the study. A two-week rest period followed
the final induction application. Following the rest period, a challenge
application of the test substance (0.2 gram) was made to each subject.
During the challenge application, the test substance remained in contact
with the skin (at a naïve site) for a period of approximately 24 hours.
Observations of the challenge sites were conducted at 24 and 72 hours
post application. No dermal responses were noted at the challenge sites
during the two examinations. Under the conditions of this study, Resin
acids and Rosin acids, hydrogenated, Me esters did not cause a skin
sensitization reaction in humans.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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