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Environmental fate & pathways

Hydrolysis

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Administrative data

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
SEP 2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
yes (incl. QA statement)
Radiolabelling:
no
Analytical monitoring:
yes
Details on sampling:
Due to variability and/or an increase in concentration between the 0 hours and 120 hours results, additional samples were taken after 144 hours (pH 4, 7 and 9); 168 and 264 hours (pH 4 and 7).
Buffers:
Sterile buffer solutions at pH's 4, 7 and 9.
Specification of buffer solutions (Concentration in mmol dm-3):
pH 4: Citric acid 0.6; Sodium chloride 0.4; Sodium hydroxide 0.7
pH 7: Disodium hydrogen orthophosphate (anhydrous) 0.3; Potassium dihydrogen orthophosphate 0.2; Sodium chloride 0.2
pH 9: Disodium tetraborate 0.1; sodium chloride 0.2
Duration:
264 h
pH:
4
Temp.:
50 °C
Initial conc. measured:
>= 0.001 - <= 0.001 g/L
Duration:
264 h
pH:
7
Temp.:
50 °C
Initial conc. measured:
>= 0.001 - <= 0.001 g/L
Duration:
144 h
pH:
9
Temp.:
50 °C
Initial conc. measured:
>= 0.001 - <= 0.001 g/L
Number of replicates:
2 replicates per pH value
Positive controls:
not specified
Negative controls:
not specified
Preliminary study:
Sample solutions at pH 4, 7 and 9 were maintained at 50.0 ± 0.5 °C for a period of at least 120 hours. The decrease in concentration was less than 10 % and no further testing was nessecary.
Transformation products:
not specified
% Recovery:
>= 93 - <= 94.4
pH:
4
Temp.:
50 °C
Duration:
264 h
% Recovery:
>= 97.1 - <= 125
pH:
7
Temp.:
50 °C
Duration:
264 h
% Recovery:
>= 116 - <= 121
pH:
9
Temp.:
50 °C
Duration:
144 h
Key result
pH:
4
Temp.:
25 °C
DT50:
> 1 yr
Type:
not specified
Remarks on result:
other: Estimated from results at 50 °C
Key result
pH:
7
Temp.:
25 °C
DT50:
> 1 yr
Type:
not specified
Remarks on result:
other: Estimated from results at 50 °C
Key result
pH:
9
Temp.:
25 °C
DT50:
> 1 yr
Type:
not specified
Remarks on result:
other: Estimated from results at 50 °C
Validity criteria fulfilled:
yes
Conclusions:
It was determined that test item is not hydrolyzed at pH 4, 7 and 9 and the half-life is expected to be greater than 1 year at 25 ºC.
Executive summary:

The hydrolysis of test item was determined according to OECD Guideline 111, under GLP compliance. It was determined that test item is not hydrolyzed at pH 4, 7 and 9 and the half-life is expected to be greater than 1 year at 25 ºC.

Description of key information

The hydrolysis of test item was determined according to OECD Guideline 111, under GLP compliance. It was determined that test item is not hydrolyzed at pH 4, 7 and 9 and the half-life is expected to be greater than 1 year at 25 ºC.

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr
at the temperature of:
25 °C

Additional information