[N,N,N',N',N'',N''-hexaethyl-29H,31H-phthalocyaninetrimethylaminato(2-)-N29,N30,N31,N32]copper tris(dodecylbenzenesulphonate)

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study which meets basic scientific principles.

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Reference 2

Reference Type:

other company data

Title:

Unnamed

Year:

2002

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

5 mice per sex per dose were administered a single dose of the test substance via intraperitoneal injection. Clinical signs and body weight were monitored and necropsy was carried out at termination or after death if an animal died during the study. Observation period was until day 7 following treatment.

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

[N,N,N',N',N'',N''-hexaethyl-29H,31H-phthalocyaninetrimethylaminato(2-)-N29,N30,N31,N32]copper tris(dodecylbenzenesulphonate)

EC Number:

278-150-3

EC Name:

[N,N,N',N',N'',N''-hexaethyl-29H,31H-phthalocyaninetrimethylaminato(2-)-N29,N30,N31,N32]copper tris(dodecylbenzenesulphonate)

Cas Number:

75247-18-6

Molecular formula:

C47 H49 Cu N11 .3 C18 H30 O3 S

IUPAC Name:

Copper,N,N,N',N',N'',N''-hexaethyl-29H,31H-phthalocyanine-C,C,C-trimethanaminato(2-)-κN29,κN30,κN31,κN32]-,dodecylbenzenesulfonate (1:3)

Details on test material:

Please refer to chapter confidential details on test material

Test animals

Species:

mouse

Strain:

NMRI

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: mean (males and females): 24 g

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

CMC (carboxymethyl cellulose)

Remarks:

0.5% in water

Details on exposure:

concentration in vehicle: 14.7%, 21.5%, 31.6%,
applied volume: 10 mL/kg bw

Doses:

1470, 2150, 3160 mg/kg

No. of animals per sex per dose:

5 mice

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: 1 h, 24 h, 48 h, 7 days and 14 days after administration

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 1 400 mg/kg bw

Based on:

test mat.

Remarks on result:

other: All animals receiving 2150 or 3160 mg/kg bw died; clinical signs: Dyspnoe, apathy, spastic movement, bad general condition

Mortality:

10/10 mice at 3160 mg/kg bw: all animals (males and females) died within 7 days
10/10 mice at 2150 mg/kg bw: all animals (males and females) died within 14 days
6/10 mice at 1470 mg/kg bw: 1 male animal died after 24 hours, 2 male animals died after 48 hours, 1 female animal died after 7 days, 2 female animals died after 14 days

Clinical signs:

Dyspnoe, apathy, spastic movement, bad general condition, delayed mortality

Body weight:

In part at the beginning: decrease in body weight

Gross pathology:

Intraabdominal substance deposition; sporadic agglutinations