Registration Dossier
Registration Dossier
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EC number: 911-915-8 | CAS number: -
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
In a study according to OECD guideline 211 an overall NOEC of 83 µg/L and a LOEC of 180 µg/L was determined. The EC10 value for survival was estimated to be 81 µg/L, with a 95% confidence interval of 51 to 129 µg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 81 µg/L
Additional information
A flow-through life-cycle toxicity test with
Daphnia magna was performed according to OECD guideline 211. The
cladoceran, Daphnia magna, was exposed to Olaflur at the following
nominal concentrations 13, 25, 50, 100 and 200 µg/L corresponding to the
mean measured concentrations of 11, 18, 42, 83 and 180 µg/L under
flow-through conditions for 21 days. There were no statistically
significant treatment-related effects on reproduction or growth at
concentrations ≤180 µg/L in comparison to the negative control. Survival
was the most sensitive biological endpoint measured in the
study. Daphnids exposed to Olaflur at a mean measured concentration of
180 µg/L had a biologically meaningful reduction in survival in
comparison to the negative control.
Consequently, the overall NOEC for the study was determined to be 83
µg/L and the LOEC was determined to be 180 µg/L. The EC10 value for
survival was estimated to be 81 µg/L, with a 95% confidence interval of
51 to 129 µg/L, while the EC20 value was estimated to be 127 µg/L, with
a 95% confidence interval of 70 to 174 µg/L. The EC50 value for survival
was empirically estimated to be greater than the highest test
concentration, since there was less than a 50% decrease in survival in
any treatment group in comparison to the negative control. Since there
was less than 10% inhibition in any treatment for the reproduction and
growth endpoints in comparison to the negative control, the IC10 and
IC20 values were empirically estimated to be >180 µg/L, the highest
concentration tested.
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