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EC number: 204-588-1 | CAS number: 122-98-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The oral LD50 was determined to be > 55 mg/kg.
The inhalation LC50 could not be determined.
The dermal LD50 was determined to be 68.7 mg/kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP non-guideline study, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- According to BASF-internal method: Two cats exposed orally to preparations of the test substance. Documentation of the clinical signs was performed over the 30 hour study period. Necropsy was performed at the end of the study.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- cat
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 4.15 kg and 2.84 kg - Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Test concentration used was 1% (v/v); aqueous solution
- Doses:
- 0.05 mL/kg
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 30 hours
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, other: clinical chemistry for methemoglobin - Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 0.05 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Corresponding to 55 mg/kg bw
- Mortality:
- No mortality observed.
- Clinical signs:
- other: Heavy breathing, cyanosis, salivation, apathy, and balance disorders were observed. After 1 day, no symptoms were observed.
- Gross pathology:
- Blackish brown blood, brown coloured lungs, pulmonary oedema, liver with yellow parts, and a bladder filled with brownish yellow urine were observed.
- Other findings:
- Methemoglobin up to 69%
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Quality of whole database:
- Four acute oral toxicity studies are available presented in three reports, with three species. One study is considered to be klimisch 4, because only very limited study information is available. All other studies are regarded as klimisch 2.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP non-guideline study, available as unpublished report, limitations in design and/or reporting but otherwise adequate for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- BASF internal method
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- Rate of air: 200 L/h
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- 0.17 mg/L
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Remarks on result:
- other: LD50 > saturated vapour pressure
- Mortality:
- No mortality observed
- Clinical signs:
- other: Mucosal irritations: bloody eyes and nasal discharge. The following day animals were without symptoms.
- Gross pathology:
- In 1 animal chronic bronchitis was observed.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- Two acute inhalation toxicity studies are avaible, performed with the same species. Both studies are regarded as klimisch 2.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data published in peer reviewed literature, restrictions in design and/or reporting but contributing to a weight of evidence assessment.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Penetration of rabbit skin is estimated by a technique closely skin to the one-day cuff method fo Draize and associates, using group of four male albino New Zealand rabbits. Based upon mortalities during a 14-day observation period the most probable LD50 and is fiducial range are estimated by the method of Thompson.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 - 3.5 kg - Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- Area of exposure: clipped trunk
- Type of wrap if used: impervious plastic film
REMOVAL OF TEST SUBSTANCE
- No washing
- Time after start of exposure: 24 hours
The animals are immobilized during the exposure period. - Duration of exposure:
- 24 hours
- No. of animals per sex per dose:
- 4 males per group
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- Most probable LD50 value and its fiducial range (± 1.96 SD) are estimated by the method of Thompson using the Tables of Weil
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 0.063 mL/kg bw
- Based on:
- test mat.
- 95% CL:
- 0.043 - 0.094
- Interpretation of results:
- highly toxic
- Remarks:
- Migrated information
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 68.7 mg/kg bw
- Quality of whole database:
- Two acute dermal toxicity studies are available, performed in two species. Both studies are regarded as klimisch 2.
Additional information
Acute toxicity: oral
Four acute oral toxicity studies are performed with three different species. In all of these studies limited information on the method of study has been reported. In the key study (BASF 1967, cat) two cats were exposed by oral gavage to 0.05 mL/kg of the test substance. After an observation period of 30 hours the animals were necropsied. No mortality was observed. Methemoglobin levels up to 69%, heavy breathing, cyanosis, salivation, apathy, and balance disorders were observed. Upon necropsy blackish brown blood, brown coloured lungs, pulmonary oedema, liver with yellow parts, and a bladder filled with brownish yellow urine were observed. In the second study (BASF 1967, rat) five US rats per sex per dose were exposed to the test substance dissolved in an aqueous emulsions of Traganth. Animals received 0.2, 1.6, 2, 2.5, 3.2 mL/kg bw (equivalent to 218, 1744, 2180, 2725, 3488 mg/kg bw) of the test substance via oral gavage. After an observation period of 7 days animal were necropsied. The LD50 was determined to be 2.5 mL/kg, which is equivalent to 2725 mg/kg bw. After one day crouching, irregular breathing, roughed fur, and sticky eyes were observed. No clinical signs were observed after three days. Crusting of the nose, a faeces smeared anus, and yellow-red dotted livers were observed upon pathology in animals that died. Surviving animals presented enlarged spleens and fatty livers. In the third study (Smyth 1962) groups of five non-fasted Carworth-Wistar male rats were exposed to the test substance via oral gavage. The dosages were arranged in a logarithmic series differing by a factor of two. Based upon mortalities during a 14-day observation period the most probable LD50 (± 1.96 SD) was estimated, by the method of Thompson, to be 2.23 mL/kg bw (2.01-2.47). In the fourth study (Bass 1942) two dogs were exposed to the test substance orally. One animal received 63 mg/kg bw and the other 140 mg/kg bw. No mortality was observed. As the rat is comparable insensitive for methemoglobin formation, the study conducted with cats was considered best appropriate for classification and labeling purposes.
Acute toxicity: inhalation
Two acute inhalation toxicity studies are performed both with rats. In both of these studies limited information on the method of study has been reported. In the first study (BASF 1967) six rats per sex were exposed to 0.17 mg/L of vaporized test substance for 8 hours. After an observation period of 7 days animals were necropsied. No mortality was observed. Mucosal irritations were observed which disappeared within one day, and upon necropsy chronic bronchitis was observed in one animal. In the second study (Smyth 1962) groups of six male or females albino rats were exposed to the test substance in an inhalation hazard test. Inhalations were continued for time periods in a logarithmic series with a ratio of two extending from one-fourth to eight hours, until the inhalation period killing about half the number of rats within 14 days was defined. No mortality was observed.
Acute toxicity: dermal
Two acute dermal toxicity studies are performed. In both of these studies limited information on the method of study has been reported. In the first study (BASF 1967) two cats were dermally exposed to 0.5 mL/kg of the test substance. Documentation of the clinical signs was performed over the 30 hour study period. Necropsy was performed at the end of the study. Heavily breathing, cyanosis, salivation, lying in the lateral position, no food consumption, and balance disorders were observed in both animals. A methemoglobin up to 83%, blackish brown blood, brown coloured lungs, pulmonary oedema, liver with yellow parts, and a bladder filled with brownish yellow urine were observed in one animal. The other animal had similar symptoms, but without the pulmonary oedema and with an empty stomach were observed upon necropsy. The LD50 was determined to be <0.5 mL/kg bw. In the second study (Smyth 1962) penetration of rabbit skin was estimated by a technique closely skin to the one-day cuff method fo Draize and associates, using group of four male albino New Zealand rabbits. Based upon mortalities during a 14-day observation period the most probable LD50 (and its fiducial range) was estimated, by the method of Thompson, to be 0.063 mL/kg bw (0.043-0.094) which is equivalent to 68.7 mg/kg bw.
Justification for selection of acute toxicity – oral endpoint
Four acute oral toxicity studies are available, performed in three species. The study on cats was considered as the most reliable study for C&L puposes, since the cat is the most sensitive species for methemoglobin formation.
Justification for selection of acute toxicity – inhalation endpoint
Two acute inhalation toxicity studies are available, performed in the same species. The study which included dose level information has been selected as key study.
Justification for selection of acute toxicity – dermal endpoint
Two acute dermal toxicity studies are available, performed in two species. The study with a 14-day observation period following administration was considered most appropriate for C&L purposes.
Justification for classification or non-classification
Based on the massive methemoglobin formation after single application of 55 mg/kg bw to cats 2-anilinoethanol has to be classified for acute toxicity cat.3: H301: Toxic if swallowed in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Based on the available information on 2 -anilinoethanol, classification for acute inhalation toxicity is not possible in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Based on a dermal LD50 of 68.7 mg/kg bw 2-anilinoethanol has to be classified for acute toxicity Cat 2: H310: Fatal in contact with skin in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
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