Registration Dossier

Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
September 28, 1989 - October 12, 1989
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
secondary source
Title:
ECHA disseminated dossier for CAS 687-47-8
Author:
ECHA
Year:
2016
Bibliographic source:
Study 1995 cited in ECHA disseminated dossier for CAS 687-47-8; Status Dec. 2016

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes (incl. QA statement)
Test type:
standard acute method
Limit test:
yes

Test material

Specific details on test material used for the study:
Purasolv EL

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
2000 mg/kg body weight
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
No mortality occcurred
Clinical signs:
other: At 1, 4 and 24 hours after treatment all animals showed moderate signs of piloerection. These signs of intoxication were not observed 48 hours after treatment and thereafter.
Gross pathology:
Macroscopic examination at the end of the observation period did not reveal any treatment-related gross alteration

Applicant's summary and conclusion

Conclusions:
According to the chosen testing conditions, Ethyl-S-lactate is virtually non toxic after single oral administration. Based on the structural similarity concerning the alkyl residue (methyl- vs. ethyl group) between Ethyl-S-lactate and Methylpyruvate and their close metabolic relationship (bilateral biotransformation between pyruvate and lactate via the lactate dehydrogenase), methylpyruvate is considered to be non toxic after single oral administration via read across.
Executive summary:

 Ethyl-S-lactate was administered to rats by oral gavage. The LD50 is higher than the upper limit for classification 2000 mg/kg bw. According to the chosen testing conditions, Ethyl-S-lactate is virtually non toxic after single oral administration. Based on the structural similarity concerning the alkyl residue (methyl- vs. ethyl group) between Ethyl-S-lactate and Methylpyruvate and their close metabolic relationship (bilateral biotransformation between pyruvate and lactate via the lactate dehydrogenase), methylpyruvate is considered to be non toxic after single oral administration via read across.