Registration Dossier
Registration Dossier
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EC number: 614-406-6 | CAS number: 68308-61-2
Endpoint summary
Administrative data
Description of key information
Additional information
Hydrolysis
According to Section 9.2.2.1 of Annex VIII Hydrolysis as a function of pH, does not need to be conducted as the substance is highly insoluble in water. As the calculated water solubility of GARDO TP10451 is 1.1734E-6 mg/L (WATERNT Program v1.01), for abiotic degradation studies it is unlikely that a method can be developed.
Biodegradation in water
The ready biodegradability of GARDO TP 10451 was studied in a closed bottle test (08/625 -322AN). The test item was exposed to activated sludge in the dark at 21.0 -21.9°C for 28 days. The oxygen measurements were performed in duplicate on days 0, 7, 14, 21 and 28. GARDO TP 10451 reached a mean of 8 % after 28 days based on its COD.
Hence, the test item is considered to be not ready biodegradable.
The study was conducted according to the OECD guideline 301 D and the EU-Guideline C.4 -E.
Adsorption/desorption
Based on its very low solubility and experiences that HPLC techniques*1 are not applicable for GARDO TP10451, an experimental determination of log Koc of GARDO TP10451 by HPLC is not feasible.
The log Koc of GARDO TP10451 was calculated by means of the PCKOC Program (v1.66) and a model as part of the STP Fugacity Model. Both part of the program compilation EPI Suite. The chemical structure of the idealized structure of GARDO TP10451 was entered by SMILES (Simplified Molecular Input Line Entry System) notations. The resulting Koc is either 1*E10 (PCKOC Program (v1.66)) or 1.1*E18 (Soil Koc calculated by model as given in STP Fugacity Model).
Both results show that GARDO TP10451 is completely adsorbed to soil or sewage sludge when coming into contact with both matrices, due to the molecular structure and the very low solubility (calculative equal or lower than 1.1734*E-6 mg/L at 25°C) of this substance.
*1 Laky, V. 2008. Feasibility Trial of the Analytical Method for the Determination of Gardo TP1045
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