Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Endpoint summary
Administrative data
Description of key information
Substance specific data on repeated dose toxicity is not required for substances registered as transported isolated intermediate >1000 t/a according to Annex VII of REACH regulation. Since the registered substance Alkaline co-precipitation products of soluble cobalt, manganese and nickel salts and the different constituents of the UVCB release the same toxicological relevant unit under physiological relevant conditions, the overall toxicity of dissolved nickel, cobalt and manganese ions can be used to assess the toxicity of the registered substance for endpoints where substance specific data is not required. Therefore, data from Nickel dihydroxide, Cobalt dihydroxide, Tricobalt tetraoxide, Trimanganese tetraoxide and Manganese dioxide are used for hazard assessment based on a worst-case mixture approach.
Nickel dihydroxide is classified for repeated dose toxicity as STOT RE 1 (H372) under the 1st ATP to the CLP. The lungs can be indentified as target organ from available studies. Manganese dioxide is classified for as STOT RE 1 (H372) with the CNS as target organ under Regulation (EC) No. 1272/2008. Based on the available data Cobalt dihydroxide, Tricobalt tetraoxide and Trimanganese tetraoxide are not classified for repeated dose toxicity under Regulation (EC) No. 1272/2008.
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Based on the mixture approach, the registered substance is classified for repeated dose toxicity as STOT RE 1 (H372) with lungs and CNS as target organs under Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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