Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-526-0 | CAS number: 107-85-7
Endpoint summary
Administrative data
Description of key information
Isopentylamine is highly corrosive to the skin and may cause severe lesions following contact to the eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin and eye irritation
Isopentylamine is a strong base (pKa = 10.7; section 4.21). As expected it was corrosive to the skin in an acute dermal toxicity rat study (occlusive dressing, exposure period 24 hours; cf. section 7.2.3). The pH is about 12 (section 4.20). Skin and eye irritation testing may therefore be waived in accordance with the REACH regulation, Annexes VII and VIII, column 2, for the sake of animal welfare, and because sufficient information is available to classify it as being corrosive to the skin.
Respiratory irritation
Primary aliphatic amines including n- andi-pentylamine cause respiratory irritation due to irritation of the upper airways in mice. The RD50values of the examined saturated n- and iso-amines with chain lengths of C3 to C8 decrease with increasing chain length. A linear relationship was obtained in a plot of Log RD50versus Log P. The RD50of n-pentylamine was 64 ppm (Gagnaire et al. 1993).
The RD50values of n- and iso-amines were very similar. It is therefore concluded that the RD50value of isopentylamine is in the range of 60 -70 ppm.
Effects on skin irritation/corrosion: highly corrosive
Effects on eye irritation: corrosive
Effects on respiratory irritation: irritating
Justification for classification or non-classification
Isopentylamine is expected to be corrosive to the skin, based on its physico-chemical properties. A supporting study confirms this assumption. Isopentylamine (0.5 mL/test site) caused irreversible full thickness skin corrosion of the intact dorsal skin of a rabbit after a 3 -minutes contact to the skin (BASF AG, 1987).
The substance is therefore to be classified under the regulations 67/548/EC (R35) and 1272/2008/EC, table 3.2.1 (corrosive, subcategory 1A).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
